Speakers of the online CAMI DAY – December 15, 2020 🗓 🗺

Eric Vibert, MD, PhD, IKO

Present and Future of Digital Twins in Liver Surgery
Launched in January 2020, the BOPA chair accelerates the development of digital technologies, in gestation or already existing, which increase the senses (vision, speech and touch) of the various actors in the block. These devices to help improve practices are tested in a 158 m2 space including an “operating showroom” made available by the Paul-Brousse AP-HP hospital. They are finalized and then quickly validated in the operating room of the Hepato-Biliary Center. The solutions tested are then distributed to the entire AP-HP, in all surgical disciplines, adults and pediatrics. In this perspective, the teams of the chair are working in close collaboration with Prof. Sabine Sarnacki, head of the pediatric visceral and urological surgery department at the Necker-Enfants Malades hospital AP-HP, and Prof. Souhayl Dahmani, head of the department of anesthesia-resuscitation at Robert-Debré AP-HP hospital.
BOPA is structured around six systemic blocks: the Human Factor Block, the Viz Block, the Bot Block, the Light Block, the Touch Block and the Block Box (by analogy with the black box in aeronautics). They cover the areas of communication between surgeon and patient, the capture of surgical images, the analysis of natural language in the operating room, augmented reality through the use of digital twins or fluorescent light, collaborative robotics or cobotics (design of collaborative robots) and the protection of operating room and patient data.
These tools allow greater precision of gesture, for example with the creation of digital organ twins that reproduce the deformation of tissues according to the surgeon’s movements on the real organ. The collection of data and the capture of images make it possible to enrich the protocols and to retrace, step by step, the stages of an intervention, while facilitating the transmission of knowledge to medical students, health professionals and patients. They will be able to better understand the context of their intervention.
Bio: Prof. Eric VIBERT, MD, PhD, is 49-year-old academic surgeon at AP-HP specialized in the liver surgery and transplantation at Paul Brousse Hospital, Villejuif, where he works 2007. He had more than 130 International Congress Communication and 30 invited plenary conferences in International meetings. With a H-index of 37, he had 188 publications on liver diseases (25 in 2020), 26 as first author and 38 in last author (See https://www.ncbi.nlm.nih.gov/pubmed/?term=vibert+e). He graduated in Innovative treatment of post-hepatectomy liver failure, U-PSUD in 2012, when he also received his habilitation to direct research. E.Vibert is currently full Professor PU-PH and researcher in surgical innovation (UPSUD and INSERM U1193), connecting people arising from different worlds, especially engineers and surgeons to reinvent practices in surgery. He was the chairman of large experimental and transversal study (iFLOW Project – ANR TecSan) including surgeon and mathematician to create numerical model of liver using intraoperative photonic tools. Among his current responsabilities, E.Vibert is co-chairman of the French national liver surgery registry (eHPBchir), principal investigator for TRANSPHIL and MODHEP1 Phase I/II trials, and member of digital innovation group at AP-HP, working to improve medical data management in his institution. Regarding industrial transfer, he is also inventor of LiverSP, a software for electronic tablet to improve patient-surgeon communication, he had developed a pneumatic ring (MID-AVR) modulating the portal vein diameter before hepatectomy and he is responsible of safety trial (CAMVIC) evaluating laparoscopic infra-red fluorescent in liver surgery founded by a large public/private consortium to improve liver cancer treatment (HECAM project). From 2019, he is chairman of large consortium including Mines Telecom School and AP-HP called BOPA or enhanced Operating room that involved surgeon, anesthesiologist, surgical nurse and mathematician, engineers, anthropologist to improve safety in operating room. BOPA is a large public/private consortium that it funded by APHP Foundation and Mines Telecom Foundation using an important financial sponsorship from Orange, Medtronics, Relyens, Boston Scientific Foundation, Richard Wolf, Getinge, Caresyntax and Capgemini.

Jessica Burgner-Kahrs, PhD

“Advances in Continuum Robotics for Medical Interventions
Continuum robots have a high potential to navigate and operate in confined spaces currently unreachable to standard robots, as their diameter to length ratio can be as low as 1:300. These robots are developed to reach targets through complex and winding trajectories, in contrast to either standard mechanical tools or stiff serial and parallel robots. This makes them particularly well suited for medical interventions and surgical applications.
The talk will provide an overview on advancements in continuum robotics research and focus on novel features such as drastically increased motion capabilities through extensibility, adjustable stiffness through scale sheaths, and higher accuracy through parallel structures.
Bio: Jessica Burgner-Kahrs is an Associate Professor with the Departments for Mathematical & Computational Sciences, Computer Science, and Mechanical & Industrial Engineering, the founding Director of the Continuum Robotics Laboratory, and Associate Director of the Robotics Institute at the University of Toronto, Canada. From 2013 to 2019 she was with Leibniz University Hannover, Germany and from 2010 to 2012 with Vanderbilt University, USA. She received her Diploma and Ph.D. in computer science from Karlsruhe Institute of Technology (KIT), Germany in 2006 and 2010 respectively.

Her research focus lies on continuum robotics and in particular on their design, modelling, planning and control, as well as human-robot interaction. Her fundamental robotics research is driven by applications in minimally-invasive surgery and maintenance, repair, and operations. In 2015, her research was recognized with the Heinz Maier-Leibnitz Prize, the Lower Saxony Science Award in the category Young Researcher, and she was entitled Young Researcher of the Year 2015 in Germany. The Berlin-Brandenburg Academy of Sciences awarded her the Engineering Science Prize in 2016. She was elected as one of the Top 40 under 40 in the category Science and Society in 2015, 2016, and 2017 by the business magazine Capital. In 2019, Dr. Burgner-Kahrs was elected as Young Global Leader from the World Economic Forum.

Quentin Boehler, PhD

Magnetic actuation in medical robotics
The last decade has seen an increasing interest in the use of magnetic actuation to steer soft and rigid robots at multiple scales. This relies on the generation of magnetic fields with an electromagnetic navigation system to apply torques and forces on systems composed of magnetic material. This technology is particularly promising to remotely control the deformation of soft structures such as continuum robots. We have been investigating several medical applications that will benefit from this approach including neurosurgeries, cardiac ablations, and ophthalmic procedures. Our research also focuses on the development of simulation frameworks and modelling tools to better characterize and design soft magnetic tools.
Bio: Quentin Boehler was born in Strasbourg in 1990. He received a M.S. degree in mechatronics from INSA Strasbourg in 2013, and a Ph.D. degree in robotics from ICube laboratory, University of Strasbourg in 2016 in collaboration with the LIRMM in Montpellier. His thesis focused on tensegrity mechanisms and variable stiffness devices with application to MR-compatible robotics, and was awarded the best thesis award from the research commission of the University of Strasbourg, and the first prize at the 2016 Ph.D. thesis awards from GDR Robotique. He joined the Multi-Scale Robotics Lab at ETH Zürich in 2017 as a postdoctoral associate under the supervision of Bradley J. Nelson. He is currently senior scientist and his research is on magnetic actuation for medical robotics, including the development and analysis of electromagnetic navigation systems, and of soft magnetic robots.

Franklin Okoli, PhD

Rapidly-exploring random trees for creating Non-Coplanar VMAT Treatment planning
We present a new method for non-coplanar VMAT treatment planning using Rapidly-exploring random trees. This algorithm is introduced to deal with the inefficient treatment trajectories that arise from inserting intermediate control points when beam selection methods are applied to non-coplanar VMAT treatment planning. The use of RRT method eliminates aperture contention issues that could occur from such inefficient trajectories. The RRT method enables the simultaneous plan optimization and trajectory generation. The algorithm progressively samples the space of the input candidate beam orientations to build a tree consisting of nodes and edges. During the tree-construction, fluence intensity optimization is performed simultaneously to search for delivery trajectories with optimal dosimetry. A depth-first search is done after the tree construction to enumerate all valid trajectories on the tree. The trajectory which contains the treatment plan with the lowest objective function value is selected as the best.  Treatment plans using Liver, TG-119 and Prostate cases were prepared and compared to a beam selection approach to non-coplanar VMAT planning. The results show that treatment plans of a comparable dosimetry to the beam selection approach can be obtained using this approach with fewer v control points trajectory and a lower trajectory delivery times.
Bio: Born in 1987 in Umuahia Nigeria, Franklin OKOLI graduated from Federal Government College Enugu (2005), Nnamdi Azikiwe University Awka (B.eng Electronics and Computer Engineering 2010). From 2012 to 2013 he worked as a Process Control and Automation Technician at SABMiller Intafact Onitsha and from 2013 to 2014 he was a Management Trainee at Nestle Nigeria. Franklin was awarded a scholarship byTotal S.A. in 2014 to study a Masters degree in France. He was a student at École Centrale Nantes (M.eng Automation and Robotics Engineering 2016). From 2016 to 2019 he was a PhD student at LATIM CHU Brest (INSERM UMR 1101) in the team ACTION working on the subject “Non-coplanar VMAT treatment planning optimization” a thesis co-financed by Region Bretagne and Labex-CAMI.